NFKB1 and severe combined immunodeficiency: NF-κβ is thus released from its inhibitory Iκβ complex in the cytoplasm, and it translocates into the nucleus to regulate gene expression.176–178 This canonical PKCθ–IKKβ–NF-κβ pathway is extremely important for T cell survival, homeostasis, activation, and effector function.179 Deregulation of this pathway can cause defective T cell survival and activation, autoimmunity, SCID, and lymphoma.180–182