We found that genes in the NF-κB, JAK/STAT and TGFβ/SMAD signaling pathways were not only correlated with IKBIP in gene expression but also affected the survival of glioma patients, which indirectly indicated that these 3 pathways (NF-κB, JAK/STAT and TGFβ/SMAD signaling pathways) may interact with IKBIP to affect the progression of glioma. The gene discussed is IKBIP; the disease is glioma.