We found that circRNAs (hsa_circ_0072389, hsa_circ_0072386, hsa_circ_0008621, hsa_circ_0072387, and hsa_circ_007239) that bind to miR-338-5p in glioma were all transcribed from the same host gene HMGCS1. Here, HMGCS1 is linked to central nervous system cancer.