Furthermore, although we revealed that hsa_circ_0072389, hsa_circ_0072386, hsa_circ_0008621, hsa_circ_0072387, and hsa_circ_007239 all originate from the same host gene HMGCS1, limited expression data of circRNAs in glioma prevents us from further investigating differences among these five circRNAs. Here, HMGCS1 is linked to central nervous system cancer.