In summary, we believe that hsa_circ_0072389, hsa_circ_0072386, hsa_circ_0008621, hsa_circ_0072387, and hsa_circ_0072391 induce the NF-κB and JAK/STAT pathways to aggravate glioma via miR-338-5p/IKBIP. The gene discussed is IKBIP; the disease is central nervous system cancer.