Genetic analysis in families or population, such as genome-wide association studies (GWAS) revealed a lot of susceptibility genes/loci confer risk to the incidence of CAD or ischemic stroke, and some of them, including ANRIL in 9p21, PCSK9 in 1p32 and BRG1 in 19p13 were found to confer risk for both CAD and ischemic stroke [7]. The gene discussed is SMARCA4; the disease is ischemic stroke.