Previously, GWAS and candidate gene based association studies have shown that variants in the NINJ2 gene confer risk to the incidence of ischemic stroke in several independent populations, including Chinese, Korean, Iranian and Caucasian ancestry [9–14], however, the detailed mechanisms of how NINJ2 regulates endothelial activation are not very clear, and the relationship between NINJ2 and endothelial activation also need to be confirmed in other type of atherosclerosis related disease including CAD. Here, NINJ2 is linked to ischemic stroke.