In a previous study, we found that ninjurin2 (encode by NINJ2) is expressed in human vascular endothelial cells, and can regulate the expression of genes associated with inflammation and atherosclerosis (IL-1β, TNF-α, IL-8, IL-6, ICAM-1 and E-selectin) in HUVECs. The gene discussed is TNF; the disease is atherosclerosis.