SCS of immune cells in NSCLC revealed that there is a transformation process between M1 and M2 macrophages, and the upregulation of Interferon Regulatory Factor 2 (IRF2), IRF7, IRF9, and STAT2 (Signal transducer and activator of transcription 2) transcription factors may promote differentiation to M2 [55]. This evidence concerns the gene STAT2 and non-small cell lung carcinoma.