Other studies have shown that TAM groups can promote tumor growth [56, 57].Moreover, The advent of the spatial transcriptome has provided more specific insight into the tumor microenvironment, and investigators have found that in cutaneous squamous cell carcinoma, macrophages and Treg were found to be most abundant at the interstitial boundary of the tumor, while CD8 T cells and neutrophils were largely excluded from the tumor, suggesting that Treg localization may prevent effector lymphocytes from entering the tumor causing the presence of immunosuppression in the microenvironment [58]. The gene discussed is CD8A; the disease is neoplasm.