HK2 and cancer: Analysis of HK1 and HK2 mRNA expression in the Cancer Cell Line Encyclopedia [33] revealed that endometrial and ovarian cancer cell lines express both HK1 and HK2. Moderate-to-strong expression of HK1 and HK2 (defined as > 10 TPM (transcripts per million)) was detectable in the vast majority of analyzed cell lines (Table S2).