NLRP2 and COVID-19: Expanding beyond these situations and integrating our computational predictions with empirical data on SARS-COV-2 infection in human whole blood, we found a CpG site in NLRP2 that was not only differentially methylated in COVID-19 positive males compared to COVID-19 negative males, but also displayed a relatively larger magnitude of DNA methylation difference by COVID-19 status in males relative to females.