PTPRN2 and Marfan syndrome: Upon studying these genes for a possible role in MFS, four genes (FNBP1, EHBP1, SDK1, and PTPRN2) were found to be involved in cytoskeletal actin dynamics, which regulates cell-adhesion and cellular uptake or secretion [23–26], which is altered in MFS cells [27], and thought to play a role in aneurysm formation [28].