HLA-DRB1 and rheumatoid arthritis: By contrast, HLA-DQA1*03:03 (OR = 0.44, p = 2.84 × 10-29), DQB1*0401 (OR = 0.43, p = 5.20 × 10-29), and DRB1*0405 (OR = 0.41, p = 2.51 × 10-33) were more frequently observed in patients with RA.