We ascertained that HLA-DQA1*05:01 (OR = 2.35, p = 1.48 × 10-21), DQB1*0201 (OR = 2.35, p = 2.44 × 10-21), and DRB1*0301 (OR = 2.34, p = 2.87 × 10-21) were associated with SLE. The gene discussed is HLA-DRB1; the disease is systemic lupus erythematosus.