Subsequently, tumor size (P=0.014, HR=2.06, 95%CI: 1.16~3.68), necorsis of tumor (P=0.002, HR=2.60, 95%CI: 1.44~4.71), mitotic index (P=0.020, HR=2.60, 95%CI: 1.44~4.71), and low SOCS6 expression (P=0.018, HR=2.10, 95%CI: 1.14~3.89) were demonstrated by multivariate Cox proportional hazard regression model analysis to be independent predictive factors for RFS (shown in Table 3). This evidence concerns the gene SOCS6 and neoplasm.