SOCS6 and gastrointestinal stromal tumor: Then it was revealed by univariate Cox proportional hazard regression model analysis that tumor size (P<0.001, HR=3.18, 95%CI: 1.84~5.50), tumor location (P=0.012, HR=1.95, 95%CI: 1.16~3.30), necorsis of tumor (P<0.001, HR=3.93, 95%CI:2.31~6.68), mitotic index (P<0.001, HR=2.93, 95%CI: 1.73~4.97), moderate or high NIH risk grade (P<0.001, HR=8.89, 95%CI: 3.53~22.36) and low SOCS6 expression (P=0.009, HR=2.20, 95%CI: 1.22~3.98) were significantly associated with RFS of GIST patients (shown in Table 3).