According to Kaplan-Meier curve analysis, low SOCS6 expression (P=0.0071), non-stomach GIST (P=0.0107), tumor size>5 cm (P<0.001), necrosis of tumor (P<0.001), Mitotic index>5/50HPF(P<0.001), moderate or high NIH risk grade (P<0.001) were significantly associated with worse RFS of GIST patients (shown in Fig. 4A and F). This evidence concerns the gene SOCS6 and gastrointestinal stromal tumor.