According to Kaplan-Meier curve analysis, low SOCS6 expression (P=0.0059), tumor size>5 cm (P<0.001), necrosis of tumor (P<0.001), Mitotic index>5/50HPF(P=0.0001), moderate or high NIH risk grade (P<0.001) were significantly associated with worse OS of GIST patients (shown in Fig. 3A and E). Here, SOCS6 is linked to gastrointestinal stromal tumor.