Then it was revealed by univariate Cox proportional hazard regression model analysis that tumor size (P<0.001, HR=3.67, 95%CI: 1.99~6.74), necorsis of tumor (P<0.001, HR=4.50, 95%CI:2.48~8.18), mitotic index (P<0.001, HR=3.13, 95%CI: 1.75~5.62), moderate or high NIH risk grade (P<0.001, HR=7.37, 95%CI: 2.90~18.73) and low SOCS6 expression (P=0.008, HR=2.51, 95%CI: 1.27~4.93) were significantly associated with OS of GIST patients (shown in Table 2). This evidence concerns the gene SOCS6 and gastrointestinal stromal tumor.