The comparison of individual gene expression (Fig. 2B) reveals that the low dose radiation on the secondary tumor significantly upregulated expression of the genes, such as Cd8a, Ifngr1, GzmK, Cd86, Cd83, Casp3, etc. The addition of NBTXR3 to high- and low-dose radiation clearly affected expression of genes, such as Gzmb, Cd8a, Itgal, Ccl3, Il1a, etc., which are associated with T-cell and NK-cell function, innate immunity, and adaptive immunity (Fig. 2B). Here, CASP3 is linked to neoplasm.