However, there was a small, statistically significant decline in creatinine clearance (CrCl) among patients receiving rivaroxaban compared with patients receiving warfarin in the subgroup analysis of ROCKET-AF trial (Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation) (warfarin vs. rivaroxaban; − 3.5 ± 15.1 vs. − 4.3 ± 14.6 mL/min; P <  0.001) [6, 7]. This evidence concerns the gene F10 and atrial fibrillation.