Due to an established literature on the elevation of inflammatory markers following stress, as well as the documented role of the NLRP3 inflammasome activation in the maturation of IL1β, a powerful cytokine that has often been regarded as a “master regulator” of the neuroinflammatory response, the NLRP3 activation has also been proposed as a valuable candidate for therapeutic exploitation in stress-related disorders [93]. Here, IL1B is linked to stress-related disorder.