Rapamycin decreased phosphorylated mechanistic target of rapamycin (p-mTOR) in all cell lines and decreased phosphorylated p70-s6 kinase (p-p70S6K) in CML-1, CML-6 M, and 17CM98, but not CML-10c2. This evidence concerns the gene MTOR and chronic myelogenous leukemia, BCR-ABL1 positive.