Rapamycin decreased phosphorylated mechanistic target of rapamycin (p-mTOR) in all cell lines and decreased phosphorylated p70-s6 kinase (p-p70S6K) in CML-1, CML-6 M, and 17CM98, but not CML-10c2. Here, RPS6KB1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.