There were 808 cases of hyperbilirubinemia without G6PD deficiency, 49 cases were randomly selected for genotyping of UGT1A1, 22 cases were wild type, 21 cases were c.211G > A heterozygous mutation, 6 cases were homozygous mutation of c.211A/A. Here, UGT1A1 is linked to Hyperbilirubinemia.