In the previous study, we found that irrespective of the tissue locality and the applied differentiation protocol (thermogenic induction during differentiation: brown protocol; No thermogenic induction: white protocol; Methods), the molecular signature of the FTO normal (T/T) genotype adipocytes suggests higher thermognicity than the FTO obesity-risk genotype (C/C) adipocytes. The gene discussed is FTO; the disease is obesity due to melanocortin 4 receptor deficiency.