Through analysis of the public database, seven hub genes (UQCR11, UBE2N, ADD1, TLN1, IRAK3, LY96, and MAP3K1) have recently been found to be strongly associated with familial hypercholesterolemia and contribute to a higher risk of atherosclerosis [23]. The gene discussed is TLN1; the disease is familial hypercholesterolemia.