CCL4 and infection: Regarding the role of pDCs in vivo, the activation of this DC subtype by HSV-1 was shown not only to induce the production of IFN-α by these cells, but also stimulated naïve CD4+ T cells and led to the migration of activated T cells to the infection site thanks to the chemokines CCL4 and CXCL10 produced at the site of infection [44].