In addition, an in vivo study in mice with a cDC having a conditional deletion in the gene for Atg5 showed impaired CD4+ T cell priming after infections with HSV-1 or HSV-2, with the most pronounced defect from Atg5 deletion being the processing and presentation of phagocytosed antigens in MHC-II [137]. This evidence concerns the gene ATG5 and infection.