AGT and cyclic hematopoiesis: Correspondingly, this study showed that sinomenine upregulates Bcl-2 expression, downregulates Caspase3 and Bax expression, and decreases the apoptosis rate of Ang II-treated H9C2 cells, indicating that sinomenine may relieve CH development by stimulating the anti-apoptotic effects of Bcl-2 and intercepting the pro-apoptotic effects of Caspase3 and Bax.