For example, overexpression of miR-187-3p attenuates ischemia-reperfusion-induced pain sensitivity by inhibiting the release of P2X7R and subsequently mature IL-1β in the mouse spinal cord [55] miR-187-3p inhibits metastasis and epithelial-mesenchymal transition in hepatocellular carcinoma by targeting S100A4 [57]. The gene discussed is S100A4; the disease is hepatocellular carcinoma.