Celecoxib is a common non-steroidal anti-inflammatory drug approved for the treatment of rheumatoid arthritis due to its anti-inflammatory property by the US Food and Drug Administration (FDA), it exerts anti-inflammatory effects by suppressing the production of prostaglandin through inhibiting the activity of cyclooxygenase-2 (COX-2) [17]. Here, PTGS2 is linked to rheumatoid arthritis.