This study aims to explore the bioregulation of simvastatin in acute leukemia cell lines, the expression of miR-19a-3p and HIF-1α level in AML, the molecular mechanism of miR-19a-3p/HIF-1α in simvastatin inhibiting AML, to lay a theoretical foundation for possible clinical application in the future. Here, HIF1A is linked to acute leukemia.