For the sake of proving the role of miR-19a-3p/HIF-1α axis on the simvastatin-mediated regulation on biological function of AML cells, KG-1 cells were treated with simvastatin and silenced the expression of HIF-1α, then transfected with miR-19a-3p or not. This evidence concerns the gene HIF1A and acute myeloid leukemia.