As for the subtypes of clinicopathological features associated with prognosis, the K-M survival analysis for sub-population displayed that GDI2 expression significantly impacted the OS rate in HCC patients with certain clinical index as: Age>60 (HR=2.08(1.31-3.28); P = 0.002; Figure 6A), BMI>25 (HR=2.10(1.21-3.66); P = 0.009; Figure 6B), and AFP(ng/ml)<=400 (HR=2.01(1.21-3.35); P = 0.007; Figure 6C). This evidence concerns the gene AFP and hepatocellular carcinoma.