In view of that PID_P53 Regulation Pathway was enriched in GDI2-based GSEA analysis in our study (Figure 2H), the association of this novel protein GDI2 with transcriptional factor TP53 should be attached great importance to, as well as their interactive mechanism in HCC tumorigenesis should be studied for further confirmation. The gene discussed is GDI2; the disease is hepatocellular carcinoma.