To better understand the functional implications of GDI2 in HCC, GO and KEGG functional enrichment analyses were performed based on 1225 DEGs between high- and low-GDI2 expression, which indicated that the GDI2-associated genes engaged in 342 GO terms of biological processes (BP), 62 terms of cellular components (CC) and 74 terms of molecular function (MF). This evidence concerns the gene GDI2 and hepatocellular carcinoma.