As a robust antioxidant, vitamin C helps in normal neutrophil function, scavenging of oxidative species, regeneration of vitamin E, modulation of signaling pathways, activation of pro-inflammatory transcription factors, activation of the signaling cascade, nuclear factor κB (NFκB), regulation of inflammatory mediators, gene regulation, phagocytosis, and signaling pathways in T-cells and increases neutrophil motility to the site of infection. This evidence concerns the gene NFKB1 and infection.