The controversial roles of UHRF2 have been reported in different cancers, as its oncogenic role was reported in colorectal cancer through stabilizing TCF4 mediated Wnt/β‐catenin signaling, while it acted as a negative regulator of epithelial‐mesenchymal transition (EMT) in esophageal squamous cell carcinoma [80, 81]. Here, TCF4 is linked to esophageal squamous cell carcinoma.