It has been reported that LDNs expressing CD15+CD11b+CD33+HLA‐DR− are activated neutrophils that undergo degranulation and a series of inflammatory processes in multiple autoimmune diseases such as systemic lupus erythematosus (SLE), psoriasis, and arthritis (Fujimi et al., 2012; Goodfellow & Willison, 2016; Grand'Maison et al., 1992; Grayson et al., 2015). This evidence concerns the gene CD33 and systemic lupus erythematosus.