Constitutive expression of Lhx2 in natural hematopoietic progenitor/stem cells in vivo led to a myeloproliferative disorder and caused acute leukemia [66], which implies that the iHPCs generated in our study are different from these cells, as our iHPCs did not cause myeloid proliferation. This evidence concerns the gene LHX2 and myeloproliferative disorder.