The main findings were (1) ethanol was an appropriate solvent for extracting anti-AD compounds from D. esculentum, (2) ethanolic extracts were rich in phenolic compounds, particularly rutin and its aglycone, quercetin, that might contribute to antioxidant and inhibitory activities against AD-related enzymes, and (3) the ethanolic extract inhibited BACE-1 activities, a rate-limiting step in amyloid beta production, and also directly interfered with Aβ42 levels in Drosophila brain. The gene discussed is BACE1; the disease is Alzheimer disease.