METTL3 and metabolic dysfunction-associated steatohepatitis: Among these genes, we noted that Mettl3, an RNA methyltransferase-encoding gene, was dramatically upregulated (fold change = 3.945455) in db/db mouse livers but was not upregulated (fold change = 0.88228) in NASH mouse livers, which indicates that METTL3 may regulate NASH progression.