However, factors related to lipogenesis, fatty acid oxidation, and VLDL secretion were not changed by overexpression of Mettl3. Gene expression data suggest that fatty acid β-oxidation, lipogenesis, and VLDL secretion do not contribute to the increased liver steatosis seen in Mettl3-HKO mice. Here, METTL3 is linked to Hepatic steatosis.