KEGG pathway analysis showed that the genes with downregulated m6A peaks were associated with ribosome, metabolic pathways, HIF-1-signaling pathway, pathways in cancer, Epstein-Barr virus infection, Alzheimer’s disease, ubiquitin-mediated proteolysis, glycolysis/gluconeogenesis, protein processing in the endoplasmic reticulum, prolactin signaling pathway, and NAFLD (Supplementary Fig. 6). This evidence concerns the gene PRL and early-onset autosomal dominant Alzheimer disease.