METTL3 and fatty liver disease: We did not observe significant differences in the expression of genes related to TAG synthesis, fatty acid β-oxidation, or VLDL secretion in Mettl3-HOE mice (Supplementary Fig. 3f), which suggests that hepatic overexpression of Mettl3 ameliorates MCD-induced liver steatosis primarily by decreasing CD36-mediated free fatty acid uptake into the liver.