Among genes related to NAFLD, both m6A peaks and mRNA levels of Srebp1 (also named Srebf1) were significantly decreased (Supplementary Fig. 6, Supplementary Table 4 and Fig. 3a), which further indicates that lipogenesis likely contributes little to fatty liver observed in Mettl3-HKO mice. This evidence concerns the gene METTL3 and fatty liver disease.