Consistently, Mettl3-HKO mice also exhibited higher serum ALT activities (Fig. 2h), higher liver weights (Fig. 2i, j), more hepatic lipid droplets (Fig. 2j), and higher liver TAG levels (Fig. 2k), which indicates that Mettl3-HKO mice are more sensitive to MCD-induced NASH. Here, METTL3 is linked to metabolic dysfunction-associated steatohepatitis.