With respect to the nuclear/cytosolic translocation of METTL3 in NASH, TNFα/CDK9-mediated serine phosphorylation of METTL3 partially blocks the nuclear localization of METTL3, while inhibition of CDK9 increases the nuclear localization of METTL3. This evidence concerns the gene CDK9 and metabolic dysfunction-associated steatohepatitis.