PINK1 and Parkinson disease: To compile an overview of the PINK1 missense variants reported in disease-associated databases and population-based databases, we searched the Movement Disorder Society Genetic mutation database (MDSgene)5 and ClinVar6 databases for missense variants in PINK1 and identified 78 variants reported in EOPD or PD patients, of which 54 were also reported in the population-based Genome Aggregation Database (gnomAD)7 (Fig. 1b).