For example, two obesity-related fatty acid-binding proteins, FABP2 and FABP5, which lost their m6Am under HFD were both significantly downregulated at the protein levels (Fig. 3e and Supplementary Fig. 4c), while Fabp5 also displayed >10-fold downregulation at the mRNA level as well. This evidence concerns the gene FABP2 and obesity due to melanocortin 4 receptor deficiency.