KDM6B appears to be essential for the initiation and maintenance of NOTCH-driven acute T-cell lymphoblastic leukemia14, regulates multiple myeloma cell growth and survival by modulating the MAPK pathway15, drives glioblastoma stem cell plasticity and drug tolerance by chromatin remodeling16, and promotes migration, invasion, and stem cell-like behaviors in hepatocellular carcinoma17. The gene discussed is KDM6B; the disease is glioblastoma.