Regardless of the MYCN status, the genomic locus of KDM6B across 22-kb in length in all 7 human neuroblastomas is occupied by RNA polymerase II, which drives gene transcription, in accordance with enrichment of active gene transcription marks H3K4me1, H3K4me2, H3K4me3, H3K27Ac, H3K9-K14Ac, and H3K36me3. Here, KDM6B is linked to neuroblastoma.