MYC and neoplasm: Despite one recent study suggesting that KDM6B might be tumor suppressive in neuroblastoma67, we and others have found that KDM6B plays an important role in MYC-driven tumorigenesis and that pharmacologically targeting KDM6B by the small molecule GSK-J4 is therapeutically efficacious in multiple tumor models14,27,68–71, including high-risk neuroblastoma43.