SERPINE1 and infection: Decreased barrier function and multiorgan failure38 are characteristic for patients with Ebola infection together with increased levels of the pro-inflammatory cytokine and chemokines IL-6 and CXCL8-10.39 Furthermore, enhanced secretion of uPA and PAI-1 were found in Ebola-infected non-human primates at an early stage of infection, indicating an imbalanced coagulation system, as it has been observed for COVID-19 as well.