The results showed that relative to the levels in the shNC group, the levels of p-AKT (S473) and AKT were decreased and those of p-JNK and p-P53 were increased in both NPC cell lines after knockdown of CENP-N, while those of p-AKT (T308) and P53 were not significantly changed. This evidence concerns the gene CENPN and nasopharyngeal carcinoma.