To understand whether CENP-N in 5-8F and CNE-2Z cells promotes cell proliferation and cell cycling and inhibits apoptosis by promoting glucose metabolism, we established three groups of NPC cells—oeControl, oeCENP-N and oeCENP-N + 2-DG (a glucose analog and an inhibitor of glucose metabolism)—and examined these three groups of cells. The gene discussed is CENPN; the disease is nasopharyngeal carcinoma.