Then, we analyzed PET/CT imaging data of 21 patients with NPC and the immunohistochemical staining results of the corresponding pathological tissue sections and found that tumor glucose metabolism was increased in the primary lesions of patients with high expression of CENP-N in NPC tissues compared with those of patients with low expression (Fig. 1e and Supplementary Table 2, P < 0.05). Here, CENPN is linked to nasopharyngeal carcinoma.