There were multiple, cancer type–specific hot spots of junctions located near known oncogenes (Fig. 4) such as KIT, PDGFRA, EGFR, CDK4, MDM2 (glioma), TMPRSS2, ERG (PCa), FGFR1, and CCDN1 (BrCa). The gene discussed is TMPRSS2; the disease is central nervous system cancer.