There were multiple, cancer type–specific hot spots of junctions located near known oncogenes (Fig. 4) such as KIT, PDGFRA, EGFR, CDK4, MDM2 (glioma), TMPRSS2, ERG (PCa), FGFR1, and CCDN1 (BrCa). Here, PDGFRA is linked to posterior cortical atrophy.