There were multiple, cancer type–specific hot spots of junctions located near known oncogenes (Fig. 4) such as KIT, PDGFRA, EGFR, CDK4, MDM2 (glioma), TMPRSS2, ERG (PCa), FGFR1, and CCDN1 (BrCa). The gene discussed is KIT; the disease is invasive breast carcinoma.