As Y1 and Y5 receptors share a common promoter region, NPY5R mRNA expression was also moderately upregulated in the islets of T2D subjects (Figure 1B), but there was no significant correlation between NPY5R expression and the insulin stimulation index, HbA1c (Figure 1G and H) or BMI (Figure S1C). Here, INS is linked to type 2 diabetes mellitus.