Similarly, knockdown of hepatic LPLAT12 in the leptin-deficient ob/ob mouse model (genetic obesity model) led to reduced hepatic TAG levels through suppression of lipogenesis, indicating that LPLAT12-regulated phospholipid compositions are important regulators of SREBP-1c activation and lipogenesis (170). Here, SREBF1 is linked to obesity due to melanocortin 4 receptor deficiency.