Polymorphisms of the LPLAT7 gene promoter were also strongly associated with susceptibility to obesity in Pima Indians (118) (Table 5), and further studies are required to elucidate the biochemical activities and physiological functions of LPLAT7 that impact susceptibilities to obesity, insulin resistance, and hepatic steatosis. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.