MBOAT2 and Insulin resistance: In humans, LPLAT2 mutations cause type 1 congenital generalized lipodystrophy (CGL, also called Berardinelli–Seip lipodystrophy), a rare disorder that includes a total lack of subcutaneous body fat from birth, increased appetite, accelerated growth, and other metabolic complications including severe insulin resistance, hypertriglyceridemia, hepatic steatosis, and early onset diabetes (75).