Proinflammatory cytokines such as interleukin 1α (IL-1α), interleukin 1β (IL-1β), interleukin 6 (IL-6), tumor necrosis factor alpha (TNFα) and interferon γ (IFNγ) may play a role in the development of metabolic disorders, significantly affecting energy balance, as well as lipid and carbohydrate metabolism [1, 2]. The gene discussed is TNF; the disease is Other metabolic disease.