Beyond this direct regulation of lipoxygenase genes, the aberrant up-regulation of ferroptosis-suppressing genes such as Gpx4, Slc7a11, and Scd1 in Mll4-eKO mice supports a potentially lipogenic and ferroptosis-resistant state that confers a cellular advantage to promote the neoplasms observed in these mice. The gene discussed is GPX4; the disease is neoplasm.