TJP1 and carcinoma: Carcinoma cells show phenotypic plasticity through differentiation programs such as epithelial‐to‐mesenchymal transition (EMT), where epithelial cells lose their apical‐to‐basal polarity and cell‐to‐cell junctional integrity by disassembly of tight junctions (zona occludens 1, ZO‐1), adherence junctions (E‐cadherin, ECAD), and hemidesmosomes (integrin beta 4, ITGB4, and cytokeratins) [2, 3].