Experimental studies have shown that aberrant ECAD leads to disruption of ECAD‐beta‐catenin cell–cell junctional complex, activation of Wnt signaling, translocation of cell junctional beta‐catenin to nucleus, and induction of cancer stem cells (CSCs) [34], which are considered drivers of tumor progression and metastasis of CRC [35]. The gene discussed is CTNNB1; the disease is colorectal carcinoma.