MBP and neurodegenerative disease: In addition to anti-MBP antibodies, the MBP protein per se has been studied and used as a possible biomarker for brain tissue injury and neurodegenerative disease, both in serum and in the CSF (Barkhof et al. 1992; Katsavos and Anagnostouli 2013; Zavialova et al. 2017; Kim et al. 2018).