MAPT and blood coagulation disease: In either CM or SMA or both, elevated tau was associated with P falciparum histidine rich protein (PfHRP-2), a measure of parasite biomass; lactate dehydrogenase (LDH), a marker of cellular damage and hemolysis; total bilirubin, a marker of hemolysis and liver dysfunction; and presence of acute kidney injury, uremia, and coagulopathy (Figure 4A; eTable 2 in the Supplement).