In adipose tissue, adipocytes hypertrophy induced the expression of hypoxia-inducible factor-1α (HIF-1α) is known to enhance obesity, while HIF-1α induces LDs accumulation and mediates cross-linking of collagens for adipose tissue fibrosis [7,8], that balance of which is critical to maintaining healthy energy homeostasis [9]. The gene discussed is HIF1A; the disease is obesity due to melanocortin 4 receptor deficiency.