PPARA and obesity due to melanocortin 4 receptor deficiency: Another research demonstrated that wedelolactone with inhibitory effect on MAPK signaling pathway ablates the adipocyte differentiation [62]. Peroxisome proliferator-activated receptor (PPAR) signaling pathway: a report demonstrated that PPAR activator is therapeutic strategy to alleviate obesity via burning fat brown adipose tissue (BAT), thereby diminishing the fat overload [63].