We identified 2 key signaling pathways (PPAR signaling pathway, PI3K-Akt signaling pathway), 13 targets (PPARA, PPARD, PPARG, FABP3, FABP4, NR1H3, AKT1, IL6, VEGFA, PRKCA, FGF1, FGF2, and PHLPP1), and 4 bioactives (β-Amyrone, β-Stigmasterol, Neotocopherol, and Xanthosine) of CS against obesity. This evidence concerns the gene NR1H3 and obesity due to melanocortin 4 receptor deficiency.