The role of Nrf2 in mediating the anti-inflammatory and antiapoptotic efficacies of Ger in MTX-administered rats was supported by previous reports, which demonstrated increased expression of Nrf2 and suppressed inflammation in hepatic ischemia-reperfusion injury [40], diet-induced experimental atherosclerosis [41] and in ovalbumin-induced allergic asthma [18]. This evidence concerns the gene NFE2L2 and allergic asthma.