CDKN2A and breast neoplasm: While several cell cycle regulators such as CDKN2A (p16), CCNA2, CCNB1, and CCNE2 express at a higher level in AA breast tumors, a unique gene set comprising of PSPHL, CXCL10, CXCL11, ISG20, and GMDS is overexpressed in AA tumor stroma (Grunda et al., 2012; Martin et al., 2009).