ETS1 and breast cancer: To elucidate whether circ_0000326 regulated ETS1 expression by repressing miR-338-3p, qRT-PCR and Western blot were conducted, and it was discovered that ETS1 expression was notably up-regulated in BC tissues and cells (Figure 4(e-g)); miR-338-3p inhibitor could significantly elevate ETS1 expression in BC cell lines, and miR-338-3p inhibitor counteracted the inhibitory effect of circ_0000326 knockdown on ETS1 expression (Figure 4(h)).