AIRE and Hashimoto thyroiditis: Based on the ACMG guidelines, this variant is classified as benign.[11] Due to the multiple autoimmune conditions of this patient (pernicious anemia, lymphocytic thyroiditis, macroprolactinemia, possible lymphocytic hypophysitis, anti-CaSr antibodies), the autoimmune regulator (AIRE) gene was sequenced, but no pathogenic mutations were found.