FH and malignant adrenal gland pheochromocytoma: In addition to the above clinical manifestations, mutations in FH genes are predisposed to malignant pheochromocytomas and paragangliomas.[12] Furthermore, FH variants also account for fumaric aciduria, which is an autosomal recessive disorder characterized by brain malformations, developmental delay, and seizures, leading to early neurological impairment.