PDCD1 and neoplasm: In this report, we describe the case of an HCC patient with IVC tumor thrombus, RA tumor thrombus, and left adrenal gland metastasis who showed a favorable response after treatment with TACE, tyrosine kinase inhibitors (sorafenib, regorafenib), PD-1 inhibitor (nivolumab and toripalimab), and RT.