TNF and cerebrovascular disorder: Its main components are safflower yellow pigment, quercetin, kaempferol, and other components, which can regulate the NF-kappa B signaling pathway, the TNF signaling pathway, and other signal pathways to exert anti-inflammatory effects and prevent and treat cardiovascular and cerebrovascular diseases.[29] For example, hydroxysafflor yellow A confers neuroprotection against focal cerebral ischemia by modulating the crosstalk between the JAK2/STAT3 and SOCS3 signaling pathways.[30] The RPR-FC is a commonly used drug pair for the treatment of IS.