VEGFA signaling clearly regulates angiogenesis after IS and reduces the degree of cerebral ischemia.[35] CASP3 and signal transducer and activator of transcription 3 target VEGFA to regulate angiogenesis after cerebral ischemia and can also control the survival and regeneration of nerve cells.[36] TNF-α is a proinflammatory cytokine that can aggravate the inflammatory response of neutrophils. The gene discussed is TNF; the disease is brain ischemia.