We screened pathways and found that the RPR-FC may be involved in fluid shear stress and the atherosclerosis signaling pathway, the MAPK signaling pathway, the NF-kappa B signaling pathway, the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway, the VEGF signaling pathway, the TNF signaling pathway, and other signaling pathways to exert immunoregulatory and neuroprotective effects after IS. This evidence concerns the gene VEGFA and atherosclerosis.