Studies have shown that the methylation level of the TP53 promoter is related to neck arterial intima-media thickness and that the degree of carotid atherosclerosis and the circulating level of homocysteine in the peripheral blood are related, which indicates that TP53 is related to the pathophysiology of IS.[34] AKT1 is a serine-threonine protein kinase. The gene discussed is TP53; the disease is carotid atherosclerosis.